PRECLINICAL PUBLICATION · 2011

Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice.

Mouse / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21272128 ↗2011Reported benefit

MouseIschaemia-reperfusionHepaticBefore ischaemia (pretreatment)

Model: Hepatic ischaemia/reperfusion injury inducing acute kidney injury

S1P pretreatment attenuated systemic inflammation and endothelial/kidney injury after hepatic I/R via the S1P/S1P1 pathway.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.