A glucosylceramide synthase inhibitor protects rats against the cytotoxic effects of shiga toxin 2.
RatChemical/toxinSprague-DawleyMaleOralFrom 2 days before until 4 days after toxin injection
Model: Shiga toxin 2 injection (haemolytic uraemic syndrome model)
Oral C-9 decreased mortality to 50% and reduced renal and intestinal injury from Shiga toxin 2, with prophylactic benefit when given before challenge.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.