PRECLINICAL PUBLICATION · 2011

Down-regulation of glial fibrillary acidic protein and vimentin by RNA interference improves acute urinary dysfunction associated with spinal cord injury in rats.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

GFAP and vimentin siRNAs (RNA interference) with atelocollagen

PMID 21250919 ↗2011Reported benefit

Down-regulation of glial fibrillary acidic protein and vimentin by RNA interference improves acute urinary dysfunction associated with spinal cord injury in rats.

RatSpinal cord injuryContusionSprague-DawleyFemaleLocal application to contused spinal cord in atelocollagen

Model: Contusive thoracic spinal cord injury

Local GFAP and vimentin siRNAs suppressed intermediate filament overexpression and accelerated recovery of spontaneous voiding after spinal cord injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.