PebbleAtlas
PEBBLE / ATLAS
Open research access
PRECLINICAL PUBLICATION · 2011

Temporal and spatial patterns of endogenous danger signal expression after wound healing and in response to lymphedema.

Mouse / Wound

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21248077 ↗2011Reported benefit

Temporal and spatial patterns of endogenous danger signal expression after wound healing and in response to lymphedema.

MouseWoundC57BL/6Female

Model: Surgical mouse tail model of tissue injury and lymphedema

Endogenous danger signals HMGB1 and HSP70 were upregulated along spatial gradients in wound and lymphedema, and HMGB1 blockade reduced inflammatory lymphangiogenesis.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.