Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice.
MouseTBIControlled cortical impactC57BL/6MaleIntravenous resuscitationAfter 90 min haemorrhagic hypotension (resuscitation)
Model: Controlled cortical impact traumatic brain injury plus haemorrhagic hypotension
PNPH restored blood pressure with lower resuscitation volume and reduced hippocampal neuronal death versus Hextend and lactated Ringer's after TBI plus haemorrhage.
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