The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration.

The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration.

Model: Acute peripheral (sciatic) nerve injury for post-traumatic axonal degeneration; chronic CMT1A Pmp22 transgenic model

Nicotinamide transiently delayed acute post-traumatic axonal degeneration but did not reduce chronic axonal loss in the CMT1A rat, unlike the Wlds transgene.

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