PRECLINICAL PUBLICATION · 2010

Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21163358 ↗2010Reported benefit

RatOtherLewisOral

Model: Meniscal tear-induced joint instability (traumatic knee injury)

Oral AGG-523 significantly attenuated the injury-induced release of aggrecanase-generated aggrecan fragments into rat joint fluid.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.