PRECLINICAL PUBLICATION · 2010

A murine model of hypertonic saline as a treatment for acute spinal cord injury: effects on autonomic outcome.

Mouse / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Hypertonic saline (7.5%)

PMID 21142467 ↗2010Reported benefit

A murine model of hypertonic saline as a treatment for acute spinal cord injury: effects on autonomic outcome.

MouseSpinal cord injuryContusionC57BL/6Femalen = 417.5% hypertonic saline3 and 24 hours after injury

Model: Severe T8-10 spinal cord contusion

Hypertonic saline improved bladder function and reduced cellular infiltration after spinal cord injury, with greater benefit when given at 24 h than 3 h.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.