PRECLINICAL PUBLICATION · 2010

Opioid delta(1) and delta(2) receptor agonist attenuate myocardial injury via mPTP in rats with acute hemorrhagic shock.

Rat / Haemorrhage/shock

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 20444473 ↗2010Reported benefit

RatHaemorrhage/shockControlledSprague-DawleyMalen = 48InjectionTAN-67 10 mg/kg; Deltorphin II 1 mg/kgAt end of shock, before resuscitation

Model: Acute haemorrhagic shock (30 percent blood volume removed, 60 min)

Delta opioid receptor agonists TAN-67 and Deltorphin II protected the heart by reducing mPTP opening in acute haemorrhagic shock.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.