PebbleAtlas
THE HEADLINE FINDING

Four decades of research.
Almost no new drugs in use.

Of 333 drugs studied in trauma models from 1980–2020, none of this preclinical work produced an attributable new trauma-drug approval. Explore the evidence behind that result.

Explore the atlas Understand the research
Free to explore. Open to scrutiny.
THE TRANSLATION RESULT1980–2020
Hundreds studied.
Almost none approved.
5,033Papers analysedPublications in the evidence base
333Drugs tested in traumaDistinct drugs studied in trauma models
291Reached human trialsMostly for other, non-trauma conditions
0New trauma drugs from this workNo approvals are attributable to it
Existing approvals pre-date the corpus studies. Causal contribution is not inferred.
A field of research.
One stark result.
5,033Publications in the review
333Drugs studied in trauma
1Strict trauma approvals
0Attributable new approvals
START WITH A QUESTION

Find the evidence that matters.

For researchers asking what comes next.
For teams deciding where to invest their effort.

01

Has this approach reached humans?

Follow a therapy from rodent studies to registered clinical trials and reported regulatory status.

Explore therapies
02

What happened to the mechanism?

Look beyond individual compounds. Explore mechanism classes, clinical setbacks and gaps in the evidence.

Explore mechanisms
03

How strong is the evidence?

Return to the underlying publications, inspect provenance and understand the limits of each finding.

Explore studies
TRANSPARENT BY DESIGN

Useful evidence starts
with honest limitations.

The atlas connects a systematic review with an extended, machine-assisted evidence index. It records reported outcomes; it does not establish that an animal study caused a clinical approval.

Coverage and definitions are visible throughout. The research window is 1980–2020; clinical and regulatory information reflects the August 2026 dataset.

Read the methods and limitations